PS992 MSI2 REGULATES BACH1/BRIP1 THUS AFFECTING THE OXIDATIVE STRESS RESPONSE

Yeast oxidative stress response

Aerobic organisms are constantly exposed to reactive oxygen species (ROS), generated as normal metabolism byproducts, especially by respiration [1,2]. To modulate ROS concentrations and to counteract their deleterious effects, there are several antioxidant systems with an apparent functional redundancy, which may provide an evolutionary advantage. Saccharomyces cerevisiae cells possess multiple...

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.

Eukaryotic cells respond to unfolded proteins in their endoplasmic reticulum (ER stress), amino acid starvation, or oxidants by phosphorylating the alpha subunit of translation initiation factor 2 (eIF2alpha). This adaptation inhibits general protein synthesis while promoting translation and expression of the transcription factor ATF4. Atf4(-/-) cells are impaired in expressing genes involved i...

Oxidative stress in the hematopoietic niche regulates the cellular immune response in Drosophila

Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila.

Oxidative stress induced by high levels of reactive oxygen species (ROS) is associated with the development of different pathological conditions, including cancers and autoimmune diseases. We analysed whether oxidatively challenged tissue can have systemic effects on the development of cellular immune responses using Drosophila as a model system. Indeed, the haematopoietic niche that normally m...

Oxidative Stress Regulates Sphingosine-1-Phosphate

Ischemia reduces oxygen availability (hypoxia) and can thus lead to tissue damage. However, restoration of blood flow, or reperfusion, has been shown initiate a second phase of injury. Ischemia/reperfusion (I/R) injury has been linked to the generation of reactive oxygen species (ROS), which in turn lead to tissue damage through induction of apoptosis.1 Indeed, I/R injury is reduced by the admi...